Pex5^tm1Pec
Targeted Allele Detail

Summary

• Symbol: Pex5^tm1Pec
• Name: peroxisomal biogenesis factor 5; targeted mutation 1, Peter Carmeliet
• MGI ID: MGI:2384516
• Synonyms: Pex5^2loxP, Pex5^FL, Pex5^flox
• Gene: Pex5 Location: Chr6:124373775-124392026 bp, - strand Genetic Position: Chr6, 59.15 cM
• Alliance: Pex5^tm1Pec page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75108
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Four exons encompassing sequence encoding several tetratricopeptide repeat domains were flanked by an upstream floxed neo cassette and a downstream intronic loxP site. Transient transfection of ES cells with plasmids expressing cre resulted in the excision of the floxed neo cassette, leaving single loxP sites in the introns surrounding the four exons. (J:75108)

Expression

In Mice Carrying this Mutation:	3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Pex5 Mutation: 30 strains or lines available

References

• Original: J:75108 Baes M, et al., Generation of Pex5-loxP mice allowing the conditional elimination of peroxisomes. Genesis. 2002 Feb;32(2):177-8
• All: 18 reference(s)