Prss8^tm1Hum
Targeted Allele Detail

Summary

• Symbol: Prss8^tm1Hum
• Name: serine protease 8 (prostasin); targeted mutation 1, Edith Hummler
• MGI ID: MGI:2384519
• Synonyms: Prss8^neolox
• Gene: Prss8 Location: Chr7:127524889-127529266 bp, - strand Genetic Position: Chr7, 69.84 cM
• Alliance: Prss8^tm1Hum page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75109
• Parent Cell Line: GS1 (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: In addition to an FRT flanked neo cassette and a downstream 5' flank loxP site inserted into intron 2, a 3' flank loxP site was inserted into intron 5. The floxed region contained exons 3 through 5. Northern blot analysis showed reduced levels of transcript in heterozygous and homozygous mutant mice. (J:75109)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Prss8 Mutation: 24 strains or lines available

References

• Original: J:75109 Rubera I, et al., A conditional allele at the mouse channel activating protease 1 (Prss8) gene locus. Genesis. 2002 Feb;32(2):173-6
• All: 1 reference(s)