Prss8^tm1.1Hum
Targeted Allele Detail

Summary

• Symbol: Prss8^tm1.1Hum
• Name: serine protease 8 (prostasin); targeted mutation 1.1, Edith Hummler
• MGI ID: MGI:2384520
• Synonyms: Prss8^delta
• Gene: Prss8 Location: Chr7:127524889-127529266 bp, - strand Genetic Position: Chr7, 69.84 cM
• Alliance: Prss8^tm1.1Hum page

Early postnatal lethality and skin abnormalities in Prss8^tm1.1Hum/Prss8^tm1.2Hum Tg(KRT14-cre)1Ipc/0 mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75109
• Parent Cell Line: GS1 (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Breeding of mice carrying Prss8^tm1Hum with transgenic mice expressing cre via the EIIa promoter resulted in the excision of the floxed region containing exons 3 through 5. The FRT flanked neo cassette inserted into intron 2 remained intact. (J:75109)

Disease models

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prss8 Mutation: 24 strains or lines available

References

• Original: J:75109 Rubera I, et al., A conditional allele at the mouse channel activating protease 1 (Prss8) gene locus. Genesis. 2002 Feb;32(2):173-6
• All: 7 reference(s)