Scnn1a^tm1.2Hum
Targeted Allele Detail

Summary

• Symbol: Scnn1a^tm1.2Hum
• Name: sodium channel, nonvoltage-gated 1 alpha; targeted mutation 1.2, Edith Hummler
• MGI ID: MGI:2384529
• Synonyms: Scnn1a^tm2
• Gene: Scnn1a Location: Chr6:125297622-125321906 bp, + strand Genetic Position: Chr6, 59.32 cM
• Alliance: Scnn1a^tm1.2Hum page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75110
• Parent Cell Line: GS1 (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A floxed region containing exon 1 was excised by breeding mice possessing Scnn1a^tm1.1Ipt with transgenic mice expressing Cre under the contol of an EIIa promoter. (J:75110)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Scnn1a Mutation: 28 strains or lines available

References

• Original: J:75110 Hummler E, et al., Conditional gene targeting of the Scnn1a (alphaENaC) gene locus. Genesis. 2002 Feb;32(2):169-72
• All: 3 reference(s)