Slc8a1^tm1Yin
Targeted Allele Detail

Summary

• Symbol: Slc8a1^tm1Yin
• Name: solute carrier family 8 (sodium/calcium exchanger), member 1; targeted mutation 1, Yo-ichi Nabeshima
• MGI ID: MGI:2384549
• Synonyms: Ncx1 -
• Gene: Slc8a1 Location: Chr17:81680534-82045806 bp, - strand Genetic Position: Chr17, 51.29 cM
• Alliance: Slc8a1^tm1Yin page

Slc8a1^tm1Yin/Slc8a1^tm1Yin embryos lack identifiable vitelline blood vessels

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:65985
• Parent Cell Line: A3-1 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced a fragment of the gene containing most of exon 2. Northern blot analysis demonstrated that no detectable transcript was expressed from this allele. (J:65985)

Expression

In Mice Carrying this Mutation:	13 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc8a1 Mutation: 55 strains or lines available

References

• Original: J:65985 Wakimoto K, et al., Targeted disruption of Na+/Ca2+ exchanger gene leads to cardiomyocyte apoptosis and defects in heartbeat. J Biol Chem. 2000 Nov 24;275(47):36991-8
• All: 10 reference(s)