Summary |
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Mutation origin |
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Mutation description |
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Phenotypes |
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View phenotypes and curated references for all genotypes (concatenated display).
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Expression |
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Find Mice (IMSR) |
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Notes |
The Ldh1a-m1Neu mutation was induced by procarbazine hydrochloride. This mutation causes a change in the characteristics of the LDHA enzyme contributing to a decreased level of activity in homozygous or heterozygous mice. The resulting impaired energy metabolism of erythrocytes leads to a hemolytic anemia with reticulocytosis and hyperbilirubinemia. Affected mice do not, however, have impaired body weight, viability or fertility (J:14326).
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References |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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