Tg(UPII-SV40T)2Xrw
Transgene Detail

Summary

• Symbol: Tg(UPII-SV40T)2Xrw
• Name: transgene insertion 2, Xue-Ru Wu
• MGI ID: MGI:2384608
• Transgene: Tg(UPII-SV40T)2Xrw Location: unknown
• Alliance: Tg(UPII-SV40T)2Xrw page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: This transgene contains the mouse Upk2 (uroplakin 2) promoter and the wild-type allele of the SV40 large T antigen (TAg) gene. The founder mouse carried 10 copies of the transgene. (J:56305)

Disease models

Tumor Data

List all tumor models in MMHCdb carrying Tg(UPII-SV40T)2Xrw

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

This line carries 10 copies of the transgene. Three other lines were produced: 9 and 19, each with 2 copies of the transgene, and 29, which has 6 copies.

References

• Original: J:56305 Zhang ZT, et al., Urothelium-specific expression of an oncogene in transgenic mice induced the formation of carcinoma in situ and invasive transitional cell carcinoma. Cancer Res. 1999 Jul 15;59(14):3512-7
• All: 4 reference(s)