Eae26^B10.RIII
QTL Variant Detail

Summary

• QTL variant: Eae26^B10.RIII
• Name: experimental allergic encephalomyelitis susceptibility 26; B10.RIII
• MGI ID: MGI:2384624
• QTL: Eae26 Location: Chr7:115164922-115165010 bp Genetic Position: Chr7, cM position of peak correlated region/allele: 61.37 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: B10.RIII

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers EAE susceptibility compared to RIIIS/J. (J:73850)

Notes

This allele exhibits additive inheritance.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:73850

In order to uncover loci that interact or modify Eae2 on mouse Chromosome 15, a congenic strain was created which introgresses the Eae2 locus from experimental autoimmune encephalomyelitis (EAE) resistant strain RIIIS/J onto the genetic background of EAEsusceptible strain B10.RIII. The congenic segment spans 9.4 cM (D15Mit50) - 19.8 cM (D15Mit182) on chromosome 15. This congenic is referred to as B10.RIII-Eae2^RIIIS/J. Unexpectedly, homozygosity for RIIIS/J-derived alleles at Eae2 does not confer EAE resistance in the congenic indicating the effect of Eae2 may be epistatic or dependent on other factors. A genome scan with 111 microsatellite markers was conducted on an (RIIIS/J x B10.RIII-Eae2^RIIIS/J)F2 intercross to uncover additional EAE susceptibility loci. A locus on mouse Chromosome 7 named Eae26 was identified with significant linkage to acute disease at D7Mit253 (52.8 cM) with a LOD=3.37. B10.RIII-derived alleles appear to confer disease susceptibility in an additive fashion at Eae26.

References

• Original: J:73850 Jirholt J, et al., Identification of susceptibility genes for experimental autoimmune encephalomyelitis that overcome the effect of protective alleles at the eae2 locus. Int Immunol. 2002 Jan;14(1):79-85
• All: 1 reference(s)