H2-Ab1^b-tm1Koni
Targeted Allele Detail

Summary

• Symbol: H2-Ab1^b-tm1Koni
• Name: histocompatibility 2, class II antigen A, beta 1; targeted mutation 1, Pandelakis A Koni
• MGI ID: MGI:2384629
• Synonyms: H2-Ab1^tm1Koni, I-AB-flox, iab^neo, MHCII^fl
• Gene: H2-Ab1 Location: Chr17:34482201-34488392 bp, + strand Genetic Position: Chr17, 17.98 cM
• Alliance: H2-Ab1^b-tm1Koni page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75115
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A construct, in which the first coding exon was flanked by an upstream floxed neo cassette and a downstream loxP site, was integrated via homologous recombination. Flow cytometric analysis of splenocytes showed that the insertion of the loxP sites and neo cassette did not affect MHC-II surface expression. (J:75115)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any H2-Ab1 Mutation: 83 strains or lines available

References

• Original: J:75115 Hashimoto K, et al., A conditional null allele of the major histocompatibility IA-beta chain gene. Genesis. 2002 Feb;32(2):152-3
• All: 80 reference(s)