Tg(KLK4mHEL)6Ccg
Transgene Detail

Summary

• Symbol: Tg(KLK4mHEL)6Ccg
• Name: transgene insertion 6, Christopher C Goodnow
• MGI ID: MGI:2384632
• Synonyms: KLK3, KLK-4, mHEL, mHEL-KK
• Transgene: Tg(KLK4mHEL)6Ccg Location: unknown
• Alliance: Tg(KLK4mHEL)6Ccg page

Transgene origin

• Strain of Origin: C57BL/6JSfd

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(KLK4mHEL)6Ccg expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  chicken	LYZ (396218)

• Mutation details: A genomic fragment containing the coding exons of the chicken lysozyme gene (also known as hen egg lysozyme, HEL) was linked to the ubiquitously-active mouse H2-K^b promoter and transmembrane sequence (which included the extracellular spacer sequence, transmembrane segment, and cytoplasmic tail). Fluorescence activated cell sorting (FACS) analysis of cells from spleen, lymph node, bone marrow, and thymus from mice carrying the transgene showed membrane expression of chicken lysozyme on these cells. (J:78307)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:78307 Hartley SB, et al., Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens. Nature. 1991 Oct 24;353(6346):765-9
• All: 26 reference(s)