Sials^MRL/MpJ
QTL Variant Detail

Summary

• QTL variant: Sials^MRL/MpJ
• Name: sialoadenitis susceptibility; MRL/MpJ
• MGI ID: MGI:2384716
• QTL: Sials Location: unknown Genetic Position: Chr4, Syntenic

Variant origin

• Strain of Specimen: MRL/MpJ

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers susceptibility to sialoadenitis compared to C3H/HeJ. (J:66636)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:66636

Linkage analysis using 139 markers at a density of 10 cM was performed on an MRL/MpJ-Tnfrsf6^lpr/Tnfrsf6^lpr x (C3H/HeJ-Tnfrsf6^lpr/Tnfrsf6^lpr x MRL/MpJ-Tnfrsf6^lpr/Tnfrsf6^lpr)F1 backcross population to map loci associated with 4 types of lesions involved in collagen disease: vasculitis, glomerulonephritis, arthritis, and sialoadenitis. Parental strain MRL/MpJ-Tnfrsf6^lpr/Tnfrsf6^lpr is susceptible to collagen disease whereas parental strain C3H/HeJ-Tnfrsf6^lpr/Tnfrsf6^lpr is resistant. A locus significantly linked to sialoadenitis susceptibility, Sials, in females mapped to mouse Chromosome 4 at approximately 48.5 cM (P<0.0001 at D4Mit255). The MRL/MpJ-derived allele confers recessively inherited susceptibility to sialoadenitis in female animals at this locus. Suggestive loci were also detected for susceptibility to vasculitis (P<0.0009 at D4Mit125), glomerulonephritis (P<0.0007 at D6Mit8), arthritis in males (P<0.0009 at D15Mit183), and sialoadenitis (P<0.0009 at D10Mit20 and D10Mit259).

References

• Original: J:66636 Nose M, et al., Genome analysis of collagen disease in MRL/lpr mice: polygenic inheritance resulting in the complex pathological manifestations. Int J Cardiol. 2000 Aug 31;75 Suppl 1:S53-61; discussion S63
• All: 1 reference(s)