Pcsk1^tm1Dfs
Targeted Allele Detail

Summary

• Symbol: Pcsk1^tm1Dfs
• Name: proprotein convertase subtilisin/kexin type 1; targeted mutation 1, Donald F Steiner
• MGI ID: MGI:2384741
• Synonyms: PC1/3
• Gene: Pcsk1 Location: Chr13:75237945-75282980 bp, + strand Genetic Position: Chr13, 40.63 cM, cytoband C2
• Alliance: Pcsk1^tm1Dfs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:78369
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 and several putative transcription control elements were replaced with a neomycin selection cassette. The absence of transcript and protein in homozygous mutant mice was determined by Northern and Western blot analyses. (J:78369)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pcsk1 Mutation: 50 strains or lines available

References

• Original: J:78369 Zhu X, et al., Disruption of PC1/3 expression in mice causes dwarfism and multiple neuroendocrine peptide processing defects. Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10293-8
• All: 12 reference(s)