Hfe^tm2Nca
Targeted Allele Detail

Summary

• Symbol: Hfe^tm2Nca
• Name: homeostatic iron regulator; targeted mutation 2, Nancy C Andrews
• MGI ID: MGI:2385353
• Synonyms: Hfe-
• Gene: Hfe Location: Chr13:23886017-23894837 bp, - strand Genetic Position: Chr13, 9.88 cM, cytoband A2-A4
• Alliance: Hfe^tm2Nca page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:78536
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A LoxP site flanked neomycin resistance gene cassette replaced a segment of genomic sequence starting in exon 3 and ending in intron 4. (J:78536)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hfe Mutation: 35 strains or lines available

References

• Original: J:78536 Levy JE, et al., The C282Y mutation causing hereditary hemochromatosis does not produce a null allele. Blood. 1999 Jul 1;94(1):9-11
• All: 47 reference(s)