Cited2^tm1Ycy
Targeted Allele Detail

Summary

• Symbol: Cited2^tm1Ycy
• Name: Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2; targeted mutation 1, Yu-Chung Yang
• MGI ID: MGI:2385355
• Synonyms: Cited2^-
• Gene: Cited2 Location: Chr10:17598966-17601422 bp, + strand Genetic Position: Chr10, 7.18 cM, cytoband A2
• Alliance: Cited2^tm1Ycy page

Eye phenotype and exencephaly of Cited2^tm1Ycy/Cited2^tm1Ycy mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:78364
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding region of the endogenous gene was replaced by a neomycin selection cassette. Transcript was undetected in by Northern blot analysis of total embryonic RNA. (J:78364)

Disease models

Expression

In Mice Carrying this Mutation:	60 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	13 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cited2 Mutation: 23 strains or lines available

Notes

ES cell line = R19 (ARF1 R19 ES cells from Artemis Pharmaceuticals, Germany).

References

• Original: J:78364 Yin Z, et al., The essential role of Cited2, a negative regulator for HIF-1alpha, in heart development and neurulation. Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10488-93
• All: 9 reference(s)