Mdm2^tm2Glo
Targeted Allele Detail

Summary

• Symbol: Mdm2^tm2Glo
• Name: transformed mouse 3T3 cell double minute 2; targeted mutation 2, Guillermina Lozano
• MGI ID: MGI:2385437
• Synonyms: FM-Neo
• Gene: Mdm2 Location: Chr10:117524780-117546663 bp, - strand Genetic Position: Chr10, 66.32 cM, cytoband C1-C3
• Alliance: Mdm2^tm2Glo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75118
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A construct, in which exons 5 and 6 were flanked by a loxP site in intron 4 and a floxed neo cassette in intron 6, was incorporated at the endogenous locus via homologous recombination. The floxed exons encode amino acids 53 through 113, which encompass most of the Trp53-binding domain. (J:75118)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mdm2 Mutation: 54 strains or lines available

References

• Original: J:75118 Grier JD, et al., Conditional allele of mdm2 which encodes a p53 inhibitor. Genesis. 2002 Feb;32(2):145-7
• All: 2 reference(s)