Mdm2^tm2.1Glo
Targeted Allele Detail

Summary

• Symbol: Mdm2^tm2.1Glo
• Name: transformed mouse 3T3 cell double minute 2; targeted mutation 2.1, Guillermina Lozano
• MGI ID: MGI:2385439
• Synonyms: FM
• Gene: Mdm2 Location: Chr10:117524780-117546663 bp, - strand Genetic Position: Chr10, 66.32 cM, cytoband C1-C3
• Alliance: Mdm2^tm2.1Glo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75118
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The floxed neo cassette of Mdm2^tm2Glo was excised from intron 6 via germline expression of cre recombinase. Exons 5 and 6, encoding most of the Trp53-binding domain (residues 53 through 113), were left flanked by single loxP sites in introns 4 and 6. (J:75118)

Expression

In Mice Carrying this Mutation:	14 assay results 4 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Mdm2^tm2.1Glo

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mdm2 Mutation: 54 strains or lines available

References

• Original: J:75118 Grier JD, et al., Conditional allele of mdm2 which encodes a p53 inhibitor. Genesis. 2002 Feb;32(2):145-7
• All: 38 reference(s)