Mdm2^tm2.3Glo
Targeted Allele Detail

Summary

• Symbol: Mdm2^tm2.3Glo
• Name: transformed mouse 3T3 cell double minute 2; targeted mutation 2.3, Guillermina Lozano
• MGI ID: MGI:2385443
• Synonyms: delta exons5/6
• Gene: Mdm2 Location: Chr10:117524780-117546663 bp, - strand Genetic Position: Chr10, 66.32 cM, cytoband C1-C3
• Alliance: Mdm2^tm2.3Glo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75118
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The floxed region of Mdm2^tm2Glo, containing exons 5 and 6 and the neo cassette, was excised via the expression of cre recombinase. A single loxP site was left in between exons 4 and 7. (J:75118)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mdm2 Mutation: 54 strains or lines available

References

• Original: J:75118 Grier JD, et al., Conditional allele of mdm2 which encodes a p53 inhibitor. Genesis. 2002 Feb;32(2):145-7
• All: 2 reference(s)