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Tg(ILK3mHEL)3Ccg
Transgene Detail
Summary
Symbol: Tg(ILK3mHEL)3Ccg
Name: transgene insertion 3, Christopher C Goodnow
MGI ID: MGI:2385454
Synonyms: ILK-3, ILK-3 Ins-HEL, insHEL, RIP-HEL, RIP-mHEL
Transgene: Tg(ILK3mHEL)3Ccg  Location: unknown  
Alliance: Tg(ILK3mHEL)3Ccg page
Transgene
origin
Strain of Origin:  C57BL/6JSfd
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(ILK3mHEL)3Ccg expresses 1 gene
 
Mutation detailsA genomic fragment containing the coding exons of the chicken lysozyme gene (also known as hen egg lysozyme, HEL) was linked to a 600bp fragment of the rat insulin promoter and to the mouse H2-Kb transmembrane sequence (which included the extracellularspacer sequence, transmembrane segment, and cytoplasmic tail). The rat insulin promoter was used to direct expression of the inserted sequence specifically to pancreatic islet beta cells. Islets from mice carrying the transgene showed expression of chicken lysozyme by Western blot; spleen, thyroid, and thymus did not. (J:78309, J:156091)
Inheritance:    Not Specified
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 6 strains available      Cell Lines: 0 lines available
References
Original:  J:78309 Akkaraju S, et al., A range of CD4 T cell tolerance: partial inactivation to organ-specific antigen allows nondestructive thyroiditis or insulitis. Immunity. 1997 Aug;7(2):255-71
All:  28 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory