Pparg^tm1.1Mgn
Targeted Allele Detail

Summary

• Symbol: Pparg^tm1.1Mgn
• Name: peroxisome proliferator activated receptor gamma; targeted mutation 1.1, Mark A Magnuson
• MGI ID: MGI:2385456
• Synonyms: PPARgamma^flox, PPARgamma^lox
• Gene: Pparg Location: Chr6:115337912-115467360 bp, + strand Genetic Position: Chr6, 53.41 cM, cytoband E3-F1
• Alliance: Pparg^tm1.1Mgn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75120
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Partial cre mediated recombination of Pparg^tm1Mgn resulted in the excision of the neo cassette in intron 2. Single loxP sites remained in introns 1 and 2, flanking exon 2. (J:75120)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pparg Mutation: 41 strains or lines available

References

• Original: J:75120 Jones JR, et al., Generation and functional confirmation of a conditional null PPARgamma allele in mice. Genesis. 2002 Feb;32(2):134-7
• All: 11 reference(s)