Acsns1^A/J
QTL Variant Detail

Summary

• QTL variant: Acsns1^A/J
• Name: Angiostrongylus costaricensis nematode susceptibility 1; A/J
• MGI ID: MGI:2385461
• QTL: Acsns1 Location: Chr19:47897880-55026545 bp Genetic Position: Chr19, Syntenic

Variant origin

• Strain of Specimen: A/J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Mutation details: This allele is associated with resistance to infection with the nematode Angiostrongylus costaricensis compared to SM/J. (J:75549)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:75549

A whole genome scan using 95 markers at an average spacing of 20 cM was performed on 207 male (A/J x SM/J)F2 animals to identify loci associated with resistance/susceptibility to infection with the nematode Angiostrongylus costaricensis. Parental strain A/J shows a high survival rate (90.5%) 5 weeks post-infection whereas parental strain SM/J shows a low survival rate (33.3%). Infected SM/J animals exhibit severe anemia and reduced body weight. A locus named Acsns1, Angiostongylus costaricensis nematode susceptibility 1, mapped to distal mouse Chromosome 19 from 47 cM (D19Mit91) to 53 cM (D19Mit34) with a LOD=4.3. Homozygosity for A/J-derived alleles appears to increase survival in infected F2 animals. A potential candidate gene is Csf2ra at 51 cM on mouse Chromosome 19. Epistatic interacting loci were detected at D13Mit248 and D17Mit21. The Chromosome 13 locus is named Acsns2 and the Chromosome 17 locus is named Acsns3. Homozygosity for SM/J-derived alleles at both Acsns2 and Acsns3 confers decreased host survival (P<0.001).

References

• Original: J:75549 Ohno T, et al., Chromosomal mapping of host susceptibility loci to Angiostrongylus costaricensis nematode infection in mice. Immunogenetics. 2002 Feb;53(10-11):925-9
• All: 1 reference(s)