Srf^tm2Nor
Targeted Allele Detail

Summary

• Symbol: Srf^tm2Nor
• Name: serum response factor; targeted mutation 2, Alfred Nordheim
• MGI ID: MGI:2385464
• Synonyms: fl, Srf^f, Srf-flex1neo
• Gene: Srf Location: Chr17:46859255-46867101 bp, - strand Genetic Position: Chr17, 22.9 cM
• Alliance: Srf^tm2Nor page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75123
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A construct, in which the coding region of exon 1 was flanked by a single loxP site in the 5' untranslated region and a floxed neo cassette in intron 1, was incorporated at the endogenous locus via homologous recombination. (J:75123)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Srf Mutation: 27 strains or lines available

References

• Original: J:75123 Wiebel FF, et al., Generation of mice carrying conditional knockout alleles for the transcription factor SRF. Genesis. 2002 Feb;32(2):124-6
• All: 11 reference(s)