Sox9^tm1.1Gsr
Targeted Allele Detail

Summary

• Symbol: Sox9^tm1.1Gsr
• Name: SRY (sex determining region Y)-box 9; targeted mutation 1.1, Gerd Scherer
• MGI ID: MGI:2385469
• Synonyms: Sox9-del^ex2,3
• Gene: Sox9 Location: Chr11:112673050-112678586 bp, + strand Genetic Position: Chr11, 77.27 cM
• Alliance: Sox9^tm1.1Gsr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75124
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: This allele lacks exons 2 and 3, which encode a portion of the DNA-binding high mobility group domain and the entire transactivation domain. It can be derived from Sox9^tm1Gsr by cre recombinase excision of the loxP-flanked region containing exons 2 and 3 or from Sox9^tm2Gsr by simultaneous excision of exons 2 and 3 and of a loxP-flanked neo cassette (which has been deleted in Sox9^tm1Gsr). (J:75124)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sox9 Mutation: 33 strains or lines available

References

• Original: J:75124 Kist R, et al., Conditional inactivation of Sox9: a mouse model for campomelic dysplasia. Genesis. 2002 Feb;32(2):121-3
• All: 2 reference(s)