Trp63^tm3.2Brd
Targeted Allele Detail

Summary

• Symbol: Trp63^tm3.2Brd
• Name: transformation related protein 63; targeted mutation 3.2, Allan Bradley
• MGI ID: MGI:2385474
• Synonyms: p63^Brdm3
• Gene: Trp63 Location: Chr16:25502513-25710842 bp, + strand Genetic Position: Chr16, 17.37 cM
• Alliance: Trp63^tm3.2Brd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75125
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The ubiquitous expression of cre recombinase resulted in the excision of both the floxed region containing exons 5 through 7 and the neo cassette from Trp63^tm3Brd. Exons 5 through 7 encode the DNA-binding domain. (J:75125)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trp63 Mutation: 60 strains or lines available

References

• Original: J:75125 Mills AA, et al., Conditional inactivation of p63 by Cre-mediated excision. Genesis. 2002 Feb;32(2):138-41
• All: 4 reference(s)