Fgf17^tm1Dor
Targeted Allele Detail

Summary

• Symbol: Fgf17^tm1Dor
• Name: fibroblast growth factor 17; targeted mutation 1, David M Ornitz
• MGI ID: MGI:2385594
• Synonyms: Fgf17^-, Fgf17^neo
• Gene: Fgf17 Location: Chr14:70873643-70879708 bp, - strand Genetic Position: Chr14, 36.4 cM
• Alliance: Fgf17^tm1Dor page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:61429
• Parent Cell Line: SM1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A contstruct, in which the translational start site and two exons encoding the signal peptide were replaced by cre and neo genes, was inserted at the endogenous locus by homologous recombination. In situ hybridization showed a lack of transcript at the midbrain-hindbrain junction in homozygous mutant mice. Expression of Cre recombinase was not reported. (J:61429)

Expression

In Mice Carrying this Mutation:	8 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fgf17 Mutation: 35 strains or lines available

References

• Original: J:61429 Xu J, et al., Temporal and spatial gradients of Fgf8 and Fgf17 regulate proliferation and differentiation of midline cerebellar structures. Development. 2000 May;127(9):1833-43
• All: 11 reference(s)