Rbl1^tm1Htr
Targeted Allele Detail

Summary

• Symbol: Rbl1^tm1Htr
• Name: RB transcriptional corepressor like 1; targeted mutation 1, Hein te Riele
• MGI ID: MGI:2385659
• Synonyms: p107^-
• Gene: Rbl1 Location: Chr2:156987813-157046454 bp, - strand Genetic Position: Chr2, 78.05 cM
• Alliance: Rbl1^tm1Htr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:48194
• Parent Cell Line: IB10/E14IB10 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: Rbl1 was disrupted by insertion of a promoterless IRES Beta-geo cassette behind codon 145 via homologous recombination resulting in an in-frame termination codon originating within the IRES sequence. (J:48194)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Rbl1^tm1Htr

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rbl1 Mutation: 60 strains or lines available

References

• Original: J:48194 Robanus-Maandag E, et al., p107 is a suppressor of retinoblastoma development in pRb-deficient mice. Genes Dev. 1998 Jun 1;12(11):1599-609
• All: 16 reference(s)