Pax3^tm1.1Sjc
Targeted Allele Detail

Summary

• Symbol: Pax3^tm1.1Sjc
• Name: paired box 3; targeted mutation 1.1, Simon J Conway
• MGI ID: MGI:2385685
• Synonyms: pax3^flox
• Gene: Pax3 Location: Chr1:78077904-78173771 bp, - strand Genetic Position: Chr1, 39.79 cM
• Alliance: Pax3^tm1.1Sjc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75127
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The exon encoding two thirds of the homeodomain was flanked by a single loxP sites, created by breeding mice carrying Pax3^tm1Sjc with mice expressing cre recombinase. This resulted in an allele in which the neo cassette was removed. (J:75127)

Expression

In Mice Carrying this Mutation:	8 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pax3 Mutation: 50 strains or lines available

References

• Original: J:75127 Koushik SV, et al., Generation of a conditional loxP allele of the Pax3 transcription factor that enables selective deletion of the homeodomain. Genesis. 2002 Feb;32(2):114-7
• All: 12 reference(s)