Hoxa2^tm1.1Fmr
Targeted Allele Detail

Summary

• Symbol: Hoxa2^tm1.1Fmr
• Name: homeobox A2; targeted mutation 1.1, Filippo M Rijli
• MGI ID: MGI:2385690
• Synonyms: Hoxa2^flox
• Gene: Hoxa2 Location: Chr6:52139397-52141811 bp, - strand Genetic Position: Chr6, 25.4 cM
• Alliance: Hoxa2^tm1.1Fmr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75130
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The entire coding region was left floxed after the breeding of mice possessing Hoxa2^tm1Fmr with transgenic mice expressing Flp recombinase, which resulted in the excision of the frt flanked neo cassette from the 3' untranslated region. RT-PCR analysis of embryos homozygous for this allele showed expression levels to be reduced by 10% to 15% relative to the expression levels determined in wild-type embryos. (J:75130)

Expression

In Mice Carrying this Mutation:	9 assay results
In Structures Affected by this Mutation:	12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hoxa2 Mutation: 21 strains or lines available

Notes

ES cell line = X8.

References

• Original: J:75130 Ren SY, et al., A Hoxa2 mutant conditional allele generated by Flp- and Cre-mediated recombination. Genesis. 2002 Feb;32(2):105-8
• All: 9 reference(s)