Hoxa2^tm2Fmr
Targeted Allele Detail

Summary

• Symbol: Hoxa2^tm2Fmr
• Name: homeobox A2; targeted mutation 2, Filippo M Rijli
• MGI ID: MGI:2385711
• Synonyms: Hoxa2^{EGFP(lox-neo-lox)}
• Gene: Hoxa2 Location: Chr6:52139397-52141811 bp, - strand Genetic Position: Chr6, 25.4 cM
• Alliance: Hoxa2^tm2Fmr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75129
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A portion of exon 1, encoding the first 72 amino acids, was replaced via the insertion of the enhanced green fluorescent protein (EGFP) and a floxed neo cassette. Expression of EGFP was undetected, putatively due to the presence of the neo cassette. The deleted region corresponded to that in the conventionally targeted Hoxa2^tm1Ipc. (J:75129)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hoxa2 Mutation: 21 strains or lines available

References

• Original: J:75129 Pasqualetti M, et al., A Hoxa2 knockin allele that expresses EGFP upon conditional Cre-mediated recombination. Genesis. 2002 Feb;32(2):109-11
• All: 3 reference(s)