Hoxa2^tm2.1Fmr
Targeted Allele Detail

Summary

• Symbol: Hoxa2^tm2.1Fmr
• Name: homeobox A2; targeted mutation 2.1, Filippo M Rijli
• MGI ID: MGI:2385712
• Synonyms: Hoxa2^EGFP, Hoxa2^EGFPlox, Hoxa2^null
• Gene: Hoxa2 Location: Chr6:52139397-52141811 bp, - strand Genetic Position: Chr6, 25.4 cM
• Alliance: Hoxa2^tm2.1Fmr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75129
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: This allele, possessing sequence encoding enhanced green fluorescent protein in place of a portion of exon 1 encdoding the first 72 amino acids, was generated by breeding mice carrying Hoxa2^tm2Fmr with mice expressing cre recombinase in the germline. Expression of EGFP detected in heterozygous mutant embryos followed the expression pattern of the endogenous gene. The deleted region corresponded to the region targeted in Hoxa2^tm1Ipc. (J:75129)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hoxa2 Mutation: 21 strains or lines available

References

• Original: J:75129 Pasqualetti M, et al., A Hoxa2 knockin allele that expresses EGFP upon conditional Cre-mediated recombination. Genesis. 2002 Feb;32(2):109-11
• All: 11 reference(s)