Lhx1^tm2.1Bhr
Targeted Allele Detail

Summary

• Symbol: Lhx1^tm2.1Bhr
• Name: LIM homeobox protein 1; targeted mutation 2.1, Richard R Behringer
• MGI ID: MGI:2385716
• Synonyms: Lhx1^fx2, Lhx1^loxP, Lim1^flox, Lim1-floxed
• Gene: Lhx1 Location: Chr11:84409110-84416361 bp, - strand Genetic Position: Chr11, 51.31 cM
• Alliance: Lhx1^tm2.1Bhr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75126
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The entire coding region of the endogenous gene was left flanked by single loxP sites after the neo cassette inserted downstream of the stop codon was excised via the breeding of mice carrying Lhx1^tm2Bhr with transgenic mice expressing cre recombinase via the ubiquitous CMV promoter. (J:75126)

Expression

In Mice Carrying this Mutation:	71 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	13 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lhx1 Mutation: 22 strains or lines available

References

• Original: J:75126 Kwan KM, et al., Conditional inactivation of Lim1 function. Genesis. 2002 Feb;32(2):118-20
• All: 22 reference(s)