Ptpre^tm1Ael
Targeted Allele Detail

Summary

• Symbol: Ptpre^tm1Ael
• Name: protein tyrosine phosphatase receptor type E; targeted mutation 1, Ari Elson
• MGI ID: MGI:2385777
• Synonyms: PTPepsilon^-, Ptpre^-
• Gene: Ptpre Location: Chr7:135139210-135288022 bp, + strand Genetic Position: Chr7, 81.27 cM
• Alliance: Ptpre^tm1Ael page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:63866
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 13-15 which encode amino acids 262-411 and contain the catalytic residue C277 were replaced with a neomycin resistance gene via homologous recombination. This region of the genome was targeted to delete both transmembrane and cytoplasmic forms of the protein. Absence of protein expression in homozygous mutant animals was verified by Western blot analysis of brain, lung, testes, spleen, and Schwann cells. (J:63866)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptpre Mutation: 40 strains or lines available

References

• Original: J:63866 Peretz A, et al., Hypomyelination and increased activity of voltage-gated K(+) channels in mice lacking protein tyrosine phosphatase epsilon. EMBO J. 2000 Aug 1;19(15):4036-45
• All: 10 reference(s)