Ltb4r1^tm1Bodd
Targeted Allele Detail

Summary

• Symbol: Ltb4r1^tm1Bodd
• Name: leukotriene B4 receptor 1; targeted mutation 1, Bodduluri Haribabu
• MGI ID: MGI:2385781
• Synonyms: BLTR^-, BTL1^-
• Gene: Ltb4r1 Location: Chr14:56003419-56005951 bp, + strand Genetic Position: Chr14, 28.19 cM
• Alliance: Ltb4r1^tm1Bodd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:63874
• Parent Cell Line: AK7 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: 706 bp of the coding region was replaced with a PGK-neo cassette via homologous recombination resulting in the deletion of amino acids 81-316 from the encoded protein. Homozygous mutant animals were identified by PCR genotype analysis and Southern blot. (J:63874)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ltb4r1 Mutation: 20 strains or lines available

References

• Original: J:63874 Haribabu B, et al., Targeted disruption of the leukotriene B(4) receptor in mice reveals its role in inflammation and platelet-activating factor-induced anaphylaxis [see comments]. J Exp Med. 2000 Aug 7;192(3):433-8
• All: 14 reference(s)