Hsd11b1^tm1Yko
Targeted Allele Detail

Summary

• Symbol: Hsd11b1^tm1Yko
• Name: hydroxysteroid 11-beta dehydrogenase 1; targeted mutation 1, Yuri V Kotelevtsev
• MGI ID: MGI:2385796
• Synonyms: 11beta-HSD-1-, 11beta-HSD1-, HSD1-
• Gene: Hsd11b1 Location: Chr1:192903917-192946345 bp, - strand Genetic Position: Chr1, 97.67 cM
• Alliance: Hsd11b1^tm1Yko page

Hsd11b1^tm1Yko/Hsd11b1^tm1Ykomice show lipid accumulation in the liver

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:37960
• Parent Cell Line: CGR8 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette containing a human beta actin promoter replaced a genomic sequence encompassing exons 3 and 4. Northern blot analyses of liver and brain did not detect mRNA in homozygous mutant mice. Enzyme function analyses of tissues from homozygous mutant mice detected less than 5% of wild-type enzyme levels in liver and did not detect enzyme in brain. (J:45085)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hsd11b1 Mutation: 28 strains or lines available

References

• Original: J:37960 Kotelevtsev YV, et al., Inactivation of 11 beta-hydroxysteroid dehydrogenase type 1 by gene targeting in mice. Endocr Res. 1996;22(4):791-792
• All: 33 reference(s)