Ren2^tm1Mgfs
Targeted Allele Detail

Summary

• Symbol: Ren2^tm1Mgfs
• Name: renin 2 tandem duplication of Ren1; targeted mutation 1, Matthew G F Sharp
• MGI ID: MGI:2385805
• Synonyms: Ren-2-
• Gene: Ren2 Location: unknown Genetic Position: Chr1, Syntenic
• Alliance: Ren2^tm1Mgfs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:37967
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neomycin resistance cassette replaced exon 4 and parts of exon 3 and 5. Analysis of transcripts by a dideoxynucleotide primer extension assay did not detect transcript in kidney or submandibular gland from homozygous mutant mice. (J:37967)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ren2 Mutation: 0 strains or lines available

References

• Original: J:37967 Sharp MG, et al., Targeted inactivation of the Ren-2 gene in mice. Hypertension. 1996 Dec;28(6):1126-31
• All: 1 reference(s)