Tpm1^tm1Jse
Targeted Allele Detail

Summary

• Symbol: Tpm1^tm1Jse
• Name: tropomyosin 1, alpha; targeted mutation 1, Jonathan G Seidman
• MGI ID: MGI:2385810
• Gene: Tpm1 Location: Chr9:66929872-66956688 bp, - strand Genetic Position: Chr9, 36.27 cM
• Alliance: Tpm1^tm1Jse page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:44952
• Parent Cell Line: C1 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The neo gene was inserted in the opposite orientation via homologous recombination at a splice junction between intron 8 and exon 9a, which also deletes 32 bp of endogenous DNA. Northern blot of E8.5 embryos using probes to exon 9a and exon 9d did not detect gene transcripts in homozygous mutants. (J:44952)

Expression

In Mice Carrying this Mutation:	13 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tpm1 Mutation: 31 strains or lines available

References

• Original: J:44952 Blanchard EM, et al., Targeted ablation of the murine alpha-tropomyosin gene. Circ Res. 1997 Dec;81(6):1005-10
• All: 1 reference(s)