Lamp2^tm1Psa
Targeted Allele Detail

Summary

• Symbol: Lamp2^tm1Psa
• Name: lysosomal-associated membrane protein 2; targeted mutation 1, Paul Saftig
• MGI ID: MGI:2385811
• Synonyms: LAMP-2^-, Lamp2^tm1Psf
• Gene: Lamp2 Location: ChrX:37490234-37545331 bp, - strand Genetic Position: ChrX, 22.67 cM
• Alliance: Lamp2^tm1Psa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:64151
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The gene was disrupted by insertion of a neomycin resistance cassette into a coding exon via homologous recombination. Absence of RNA and protein expression in homozygous mutant animals was demonstrated by Northern and Western blot analysis of liver and kidney tissue. (J:64151)

Disease models

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lamp2 Mutation: 15 strains or lines available

References

• Original: J:64151 Tanaka Y, et al., Accumulation of autophagic vacuoles and cardiomyopathy in LAMP-2-deficient mice. Nature. 2000 Aug 24;406(6798):902-6
• All: 20 reference(s)