Igh-V^tm1Jjk
Targeted Allele Detail

Summary

• Symbol: Igh-V^tm1Jjk
• Name: immunoglobulin heavy chain variable region; targeted mutation 1, James J Kenny
• MGI ID: MGI:2385812
• Synonyms: V1^-
• Gene: Igh-V Location: unknown Genetic Position: Chr12, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:62284
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 3.4 kb fragment of genomic DNA containing the Igh-V gene was replaced with a PGK-neo cassette via homologous recombination. (J:62284)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igh-V Mutation: 5 strains or lines available

References

• Original: J:62284 Mi QS, et al., Highly reduced protection against Streptococcus pneumoniae after deletion of a single heavy chain gene in mouse. Proc Natl Acad Sci U S A. 2000 May 23;97(11):6031-6
• All: 3 reference(s)