Il18^tm1Khe
Targeted Allele Detail

Summary

• Symbol: Il18^tm1Khe
• Name: interleukin 18; targeted mutation 1, Klaus Heeg
• MGI ID: MGI:2385814
• Synonyms: IL-18KO
• Gene: Il18 Location: Chr9:50466127-50493140 bp, + strand Genetic Position: Chr9, 27.75 cM
• Alliance: Il18^tm1Khe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:62263
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of exons 5 and 7 and all of exon 6 were replaced with a neomycin resistance cassette via homologous recombination. Gene expression was absent in livers of homozygous mutant animals as demonstrated by RNase protection assay. (J:62263)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il18 Mutation: 32 strains or lines available

References

• Original: J:62263 Hochholzer P, et al., Role of interleukin-18 (IL-18) during lethal shock: decreased lipopolysaccharide sensitivity but normal superantigen reaction in IL-18-deficient mice. Infect Immun. 2000 Jun;68(6):3502-8
• All: 9 reference(s)