Lhx3^tm1Lmgd
Targeted Allele Detail

Summary

• Symbol: Lhx3^tm1Lmgd
• Name: LIM homeobox protein 3; targeted mutation 1, Laboratory of Mammalian Genes and Development, Heiner Westphal
• MGI ID: MGI:2385819
• Synonyms: Lhx3^-
• Gene: Lhx3 Location: Chr2:26090224-26098261 bp, - strand Genetic Position: Chr2, 18.44 cM, cytoband A2-C1
• Alliance: Lhx3^tm1Lmgd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:33050
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Sequences encoding the two LIM domains and a portion of the homeodomain were replaced with a neomycin selection cassette. Transcript was undetected by in situ hybridization analysis of mutant embryos. (J:33050)

Expression

In Mice Carrying this Mutation:	76 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lhx3 Mutation: 26 strains or lines available

References

• Original: J:33050 Sheng HZ, et al., Specification of pituitary cell lineages by the LIM homeobox gene Lhx3. Science. 1996 May 17;272(5264):1004-7
• All: 12 reference(s)