Spmap2^{Tg(PDE5A)1Ynk}
Transgenic Allele Detail

Summary

• Symbol: Spmap2^{Tg(PDE5A)1Ynk}
• Name: sperm microtubule associated protein 2; transgene insertion 1, Noriyuki Yanaka
• MGI ID: MGI:2385820
• Synonyms: ki/ki, kisimo
• Gene: Spmap2 Location: Chr10:79412311-79422970 bp, - strand Genetic Position: Chr10, 39.72 cM, cytoband B5-C1
• Alliance: Spmap2^{Tg(PDE5A)1Ynk} page

Abnormal spermatogenesis in Spmap2^{Tg(PDE5A)1Ynk}/Spmap2^{Tg(PDE5A)1Ynk} mice

Show the 1 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: C3H

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Multiple copies of a transgenic construct containing the sequence of human PDE5A inserted in tandem at the Theg locus, deleting approximately 20 kb of the genomic locus. Northern blot analysis of testis mRNA showed homozygous transgenic animals lacked transcripts of the Theg gene. (J:62271)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Spmap2 Mutation: 17 strains or lines available

References

• Original: J:62271 Yanaka N, et al., Insertional mutation of the murine kisimo locus caused a defect in spermatogenesis. J Biol Chem. 2000 May 19;275(20):14791-4
• All: 1 reference(s)