Kcnmb1^tm1Rwa
Targeted Allele Detail

Summary

• Symbol: Kcnmb1^tm1Rwa
• Name: potassium large conductance calcium-activated channel, subfamily M, beta member 1; targeted mutation 1, Richard W Aldrich
• MGI ID: MGI:2385821
• Synonyms: beta1-subunit KO, BK beta1-KO, MBeta1^-
• Gene: Kcnmb1 Location: Chr11:33913013-33923641 bp, + strand Genetic Position: Chr11, 19.32 cM
• Alliance: Kcnmb1^tm1Rwa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:65415
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2, encoding the translational start site and the first transmembrane domain, was replaced with a cassette containing lacZ and neo genes. An RNAse protection assay showed an absence of transcript in homozygous mutant mice. The expression pattern of beta-galactosidase recapitulated that of the endogenous gene. (J:65415)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kcnmb1 Mutation: 16 strains or lines available

References

• Original: J:65415 Brenner R, et al., Vasoregulation by the beta1 subunit of the calcium-activated potassium channel. Nature. 2000 Oct 19;407(6806):870-6
• All: 23 reference(s)