Cxcl15^tm1Lira
Targeted Allele Detail

Summary

• Symbol: Cxcl15^tm1Lira
• Name: C-X-C motif chemokine ligand 15; targeted mutation 1, Sergio A Lira
• MGI ID: MGI:2385827
• Synonyms: lungkine^-
• Gene: Cxcl15 Location: Chr5:90942393-90950926 bp, + strand Genetic Position: Chr5, 44.78 cM
• Alliance: Cxcl15^tm1Lira page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:67605
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: All of exons 1 and 2 and a portion of exon 3 were replaced with a neomycin selection cassette. Transcript was undetected by Northern blot analysis of lung tissue obtained from homozygous mutant mice. (J:67605)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cxcl15 Mutation: 16 strains or lines available

References

• Original: J:67605 Chen SC, et al., Impaired pulmonary host defense in mice lacking expression of the CXC chemokine lungkine. J Immunol. 2001 Mar 1;166(5):3362-8
• All: 1 reference(s)