Neurod2^tm1Tap
Targeted Allele Detail

Summary

• Symbol: Neurod2^tm1Tap
• Name: neurogenic differentiation 2; targeted mutation 1, Steven J Tapscott
• MGI ID: MGI:2385828
• Gene: Neurod2 Location: Chr11:98216241-98220471 bp, - strand Genetic Position: Chr11, 61.75 cM
• Alliance: Neurod2^tm1Tap page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:69606
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding region of the gene was replaced with an in-frame lacZ gene followed by a loxP flanked neomycin selection cassette. The neomycin selection cassette was removed in ES cells by transient Cre expression prior to the production of chimeric mice. Northern blot analysis on RNA derived from brain of homozygous mice demonstrated that no detectable transcript was expressed from this allele. (J:69606)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Neurod2 Mutation: 23 strains or lines available

References

• Original: J:69606 Olson JM, et al., NeuroD2 is necessary for development and survival of central nervous system neurons. Dev Biol. 2001 Jun 1;234(1):174-87
• All: 11 reference(s)