Jund^tm1Mya
Targeted Allele Detail

Summary

• Symbol: Jund^tm1Mya
• Name: jun D proto-oncogene; targeted mutation 1, Moshe Yaniv
• MGI ID: MGI:2385829
• Synonyms: JunD^-, Jund^tm1Wag
• Gene: Jund Location: Chr8:71151599-71153265 bp, + strand Genetic Position: Chr8, 34.15 cM, cytoband C2
• Alliance: Jund^tm1Mya page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:53906
• Parent Cell Line: CK35 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire gene was replaced with an in-frame lacZ-PGK-neo cassette via homologous recombination. Absence of gene expression was confirmed by Northern blot analysis of various tissues from homozygous mutant animals. Western blot of mouse embryonic fibroblasts derived from homozygous mutants did not detect protein product. LacZ expression was observed in mutant embryos via X-gal staining. (J:53906)

Disease models

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Jund Mutation: 3 strains or lines available

References

• Original: J:53906 Thepot D, et al., Targeted disruption of the murine junD gene results in multiple defects in male reproductive function. Development. 2000 Jan;127(1):143-53
• All: 22 reference(s)