Cd27^tm1Jbo
Targeted Allele Detail

Summary

• Symbol: Cd27^tm1Jbo
• Name: CD27 antigen; targeted mutation 1, Jannie Borst
• MGI ID: MGI:2385835
• Synonyms: CD27-, Tnfrsf7^-
• Gene: Cd27 Location: Chr6:125209585-125213973 bp, - strand Genetic Position: Chr6, 59.32 cM
• Alliance: Cd27^tm1Jbo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:65516
• Parent Cell Line: IB10/E14IB10 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding region of the gene was replaced with a PGK-hygro cassette via homologous recombination. Immunofluorescence flow cytometry of spleen cells from homozygous mutant animals confirmed the absence of protein expression. (J:65516)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cd27 Mutation: 33 strains or lines available

References

• Original: J:65516 Hendriks J, et al., CD27 is required for generation and long-term maintenance of T cell immunity. Nat Immunol. 2000 Nov;1(5):433-40
• All: 46 reference(s)