Tsg101^tm1Mak
Targeted Allele Detail

Summary

• Symbol: Tsg101^tm1Mak
• Name: tumor susceptibility gene 101; targeted mutation 1, Tak W Mak
• MGI ID: MGI:2385839
• Synonyms: tsg101-
• Gene: Tsg101 Location: Chr7:46538697-46569717 bp, - strand Genetic Position: Chr7, 30.62 cM, cytoband B5
• Alliance: Tsg101^tm1Mak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:67553
• Parent Cell Line: E14K (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: All of exon 8 and a 5' portion of exon 9 were replaced with a neomycin selection cassette. Transcript was undetected by in situ hybridization of homozygous mutant embryos. (J:67553)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tsg101 Mutation: 32 strains or lines available

References

• Original: J:67553 Ruland J, et al., p53 accumulation, defective cell proliferation, and early embryonic lethality in mice lacking tsg101. Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):1859-64
• All: 1 reference(s)