P2rx3^tm1Jwo
Targeted Allele Detail

Summary

• Symbol: P2rx3^tm1Jwo
• Name: purinergic receptor P2X, ligand-gated ion channel, 3; targeted mutation 1, John N Wood
• MGI ID: MGI:2385840
• Synonyms: P2X3^-
• Gene: P2rx3 Location: Chr2:84828927-84867806 bp, - strand Genetic Position: Chr2, 49.45 cM
• Alliance: P2rx3^tm1Jwo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:65558
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2-7 were replaced with an IRES-lacZ-neo cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by RT-PCR analysis. (J:65558)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any P2rx3 Mutation: 21 strains or lines available

References

• Original: J:65558 Souslova V, et al., Warm-coding deficits and aberrant inflammatory pain in mice lacking P2X3 receptors. Nature. 2000 Oct 26;407(6807):1015-7
• All: 2 reference(s)