Nr6a1^tm1Coo
Targeted Allele Detail

Summary

• Symbol: Nr6a1^tm1Coo
• Name: nuclear receptor subfamily 6, group A, member 1; targeted mutation 1, Austin J Cooney
• MGI ID: MGI:2385846
• Synonyms: GCNF^-
• Gene: Nr6a1 Location: Chr2:38613381-38816464 bp, - strand Genetic Position: Chr2, 24.42 cM
• Alliance: Nr6a1^tm1Coo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:67377
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The exon encoding the DNA-binding domain was replaced with a neomycin selection cassette. Transcript was undetected via in situ hybridization of homozygous mutant embryos. (J:67377)

Expression

In Mice Carrying this Mutation:	39 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	13 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nr6a1 Mutation: 145 strains or lines available

References

• Original: J:67377 Chung AC, et al., Loss of orphan receptor germ cell nuclear factor function results in ectopic development of the tail bud and a novel posterior truncation. Mol Cell Biol. 2001 Jan;21(2):663-77
• All: 7 reference(s)