Dmrt1^tm1.1Zark
Targeted Allele Detail

Summary

• Symbol: Dmrt1^tm1.1Zark
• Name: doublesex and mab-3 related transcription factor 1; targeted mutation 1.1, David Zarkower
• MGI ID: MGI:2385912
• Synonyms: Dmrt1-
• Gene: Dmrt1 Location: Chr19:25483070-25581692 bp, + strand Genetic Position: Chr19, 20.45 cM, cytoband C2-C3
• Alliance: Dmrt1^tm1.1Zark page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:65541
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The floxed sequences of Dmrt1^tm1Zark were deleted by mating mice carrying this allele to the cre-expressing TgN(ACTB-cre)2Mrt line. The cre-mediated recombination event removes the promoter, the major translation initiation codon, exon 1 (which contains the zinc-finger-like DM domain), the neomycin resistance gene, and part of intron 1. Homozygous mutant animals did not express protein product as demonstrated by immunohistochemical analysis of testes sections. (J:65541)

Expression

In Mice Carrying this Mutation:	4 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dmrt1 Mutation: 49 strains or lines available

References

• Original: J:65541 Raymond CS, et al., Dmrt1, a gene related to worm and fly sexual regulators, is required for mammalian testis differentiation. Genes Dev. 2000 Oct 15;14(20):2587-95
• All: 8 reference(s)