Pdgfb^tm2Cbet
Targeted Allele Detail

Summary

• Symbol: Pdgfb^tm2Cbet
• Name: platelet derived growth factor, B polypeptide; targeted mutation 2, Christer Betsholtz
• MGI ID: MGI:2385913
• Synonyms: PDGF-B^flox
• Gene: Pdgfb Location: Chr15:79880075-79899178 bp, - strand Genetic Position: Chr15, 37.85 cM, cytoband E
• Alliance: Pdgfb^tm2Cbet page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:78544
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 4 was floxed by insertion of a loxP-PGK-neo-loxP cassette into intron 3 and insertion of a loxP site into intron 4 via homologous recombination. (J:78544)

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pdgfb Mutation: 15 strains or lines available

Notes

Mutants in J:89186 provide a model for microvascular changes that bear striking resemblance to diabetic microangiopathy.

References

• Original: J:78544 Enge M, et al., Endothelium-specific platelet-derived growth factor-B ablation mimics diabetic retinopathy. EMBO J. 2002 Aug 15;21(16):4307-16
• All: 12 reference(s)